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APP(swe) /PS1(ΔE9) mice exhibit low oxygen saturation and alterations of erythrocytes preceding the neuropathology and cognitive deficiency during Alzheimer's disease

AIM: The molecular mechanism underlying Alzheimer's disease (AD) pathologies remains unclear. The brain is extremely sensitive to oxygen deprivation, and brief interruptions in oxygen supply may lead to permanent brain damage. The objective here was to access the red blood cell (RBC) physiologi...

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Detalles Bibliográficos
Autores principales: Wang, Manli, Chen, Xi, Niu, Long, Xu, Jianli, Yu, Hang, Xu, Xiaojiao, Yang, Qiu, Xiang, Yang, Le, Weidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10546960/
https://www.ncbi.nlm.nih.gov/pubmed/36883266
http://dx.doi.org/10.1111/cns.14147