Discovery of Potent Tetrazole Free Fatty Acid Receptor 2 Antagonists

[Image: see text] The free fatty acid receptor 2 (FFA2), also known as GPR43, mediates effects of short-chain fatty acids and has attracted interest as a potential target for treatment of various metabolic and inflammatory diseases. Herein, we report the results from bioisosteric replacement of the...

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Detalles Bibliográficos
Autores principales: Valentini, Alice, Schultz-Knudsen, Katrine, Højgaard Hansen, Anders, Tsakoumagkou, Argyro, Jenkins, Laura, Christensen, Henriette B., Manandhar, Asmita, Milligan, Graeme, Ulven, Trond, Rexen Ulven, Elisabeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547238/
https://www.ncbi.nlm.nih.gov/pubmed/37129317
http://dx.doi.org/10.1021/acs.jmedchem.2c01935

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547238/
https://www.ncbi.nlm.nih.gov/pubmed/37129317
http://dx.doi.org/10.1021/acs.jmedchem.2c01935

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