Continuous sensing of nutrients and growth factors by the mTORC1-TFEB axis

mTORC1 senses nutrients and growth factors and phosphorylates downstream targets, including the transcription factor TFEB, to coordinate metabolic supply and demand. These functions position mTORC1 as a central controller of cellular homeostasis, but the behavior of this system in individual cells h...

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Detalles Bibliográficos
Autores principales: Sparta, Breanne, Kosaisawe, Nont, Pargett, Michael, Patankar, Madhura, DeCuzzi, Nicholaus, Albeck, John G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547473/
https://www.ncbi.nlm.nih.gov/pubmed/37698461
http://dx.doi.org/10.7554/eLife.74903

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547473/
https://www.ncbi.nlm.nih.gov/pubmed/37698461
http://dx.doi.org/10.7554/eLife.74903

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