Tyrosyl-DNA phosphodiesterase 1 (TDP1) and SPRTN protease repair histone 3 and topoisomerase 1 DNA–protein crosslinks in vivo

DNA–protein crosslinks (DPCs) are frequent and damaging DNA lesions that affect all DNA transactions, which in turn can lead to the formation of double-strand breaks, genomic instability and cell death. At the organismal level, impaired DPC repair (DPCR) is associated with cancer, ageing and neurode...

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Detalles Bibliográficos
Autores principales: Anticevic, Ivan, Otten, Cecile, Vinkovic, Luka, Jukic, Luka, Popovic, Marta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547559/
https://www.ncbi.nlm.nih.gov/pubmed/37788708
http://dx.doi.org/10.1098/rsob.230113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547559/
https://www.ncbi.nlm.nih.gov/pubmed/37788708
http://dx.doi.org/10.1098/rsob.230113

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