Characterizing the impact of simvastatin co-treatment of cell specific TCDD-induced gene expression and systemic toxicity

2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is associated with metabolic syndrome (MetS) in humans and elicits pathologies in rodents that resemble non-alcoholic fatty liver disease (NAFLD) in humans through activation of the aryl hydrocarbon receptor (AHR) pathway. Dysregulation of cholesterol homeo...

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Detalles Bibliográficos
Autores principales: Jurgelewicz, Amanda, Nault, Rance, Harkema, Jack, Zacharewski, Timothy R., LaPres, John J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547718/
https://www.ncbi.nlm.nih.gov/pubmed/37789023
http://dx.doi.org/10.1038/s41598-023-42972-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547718/
https://www.ncbi.nlm.nih.gov/pubmed/37789023
http://dx.doi.org/10.1038/s41598-023-42972-8

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