Cargando…

The ascending limb of the cocaine unit dose–response function in rats as an experimental artifact

The cocaine unit dose–response function is an inverted U with the ascending and descending limbs representing the positive and rate limiting cocaine effects, respectively. Higher fixed ratio (FR) schedules and/or time-out periods make the ascending limb more prominent. Alternatively, a pharmacokinet...

Descripción completa

Detalles Bibliográficos
Autores principales: Desai, Jhanvi N., Tron Esqueda, Luis E., Norman, Andrew B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547744/
https://www.ncbi.nlm.nih.gov/pubmed/37789064
http://dx.doi.org/10.1038/s41598-023-43506-y