PLK1 maintains DNA methylation and cell viability by regulating phosphorylation-dependent UHRF1 protein stability

PLK1 is a key serine/threonine kinase as well as a master mitotic regulator, but it has never been reported that PLK1 regulates DNA methylation. In the present study, we for the first time found that PLK1 inhibition disrupted global DNA methylation and elevated the expression level of tumor suppress...

Descripción completa

Detalles Bibliográficos
Autores principales: Peng, Yuchong, Liu, Youhong, Zheng, Rirong, Ye, Yubing, Fu, Yongming, Yin, Linglong, Gao, Yingxue, Fu, Yuxin, Qi, Xuli, Deng, Tanggang, Zhang, Songwei, Li, Xiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547799/
https://www.ncbi.nlm.nih.gov/pubmed/37788997
http://dx.doi.org/10.1038/s41420-023-01667-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547799/
https://www.ncbi.nlm.nih.gov/pubmed/37788997
http://dx.doi.org/10.1038/s41420-023-01667-9

Ejemplares similares