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PLK1 maintains DNA methylation and cell viability by regulating phosphorylation-dependent UHRF1 protein stability
PLK1 is a key serine/threonine kinase as well as a master mitotic regulator, but it has never been reported that PLK1 regulates DNA methylation. In the present study, we for the first time found that PLK1 inhibition disrupted global DNA methylation and elevated the expression level of tumor suppress...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547799/ https://www.ncbi.nlm.nih.gov/pubmed/37788997 http://dx.doi.org/10.1038/s41420-023-01667-9 |