Drug holiday of high-dose denosumab and recovery from osteoclast inhibition using immunohistochemical investigation of 7 patients with medication-related osteonecrosis of the jaw undergoing segmental mandibulectomy

BACKGROUND/PURPOSE: Denosumab is used to treat bone metastases from malignant tumors. Unlike bisphosphonates, denosumab is not deposited in the bone; thus, withdrawal for a relatively short period would help recovery from osteoclast suppression. This study investigated the relationship between drug...

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Detalles Bibliográficos
Autores principales: Sawada, Shunsuke, Sakamoto, Yuki, Kirihigashi, Mako, Kojima, Yuka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Association for Dental Sciences of the Republic of China 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547948/
https://www.ncbi.nlm.nih.gov/pubmed/37799892
http://dx.doi.org/10.1016/j.jds.2023.01.021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547948/
https://www.ncbi.nlm.nih.gov/pubmed/37799892
http://dx.doi.org/10.1016/j.jds.2023.01.021

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