Intron retention decreases METTL3 expression by inhibiting mRNA export to the cytoplasm

Methyltransferase-like 3 (METTL3), a key component of the m(6)A methyltransferase complex, regulates the splicing, nuclear transport, stability, and translation of its target genes. However, the mechanism underlying the regulation of METTL3 expression by alternative splicing (AS) remains unknown. We...

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Detalles Bibliográficos
Autores principales: Lee, Sangsoo, Jung, Haesoo, Choi, Sunkyung, Cho, Namjoon, Kim, Eun-Mi, Kim, Kee Kwang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Biochemistry and Molecular Biology 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547966/
https://www.ncbi.nlm.nih.gov/pubmed/37357537
http://dx.doi.org/10.5483/BMBRep.2023-0069

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547966/
https://www.ncbi.nlm.nih.gov/pubmed/37357537
http://dx.doi.org/10.5483/BMBRep.2023-0069

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