Intra- and interchromosomal contact mapping reveals the Igh locus has extensive conformational heterogeneity and interacts with B-lineage genes

To produce a diverse antibody repertoire, immunoglobulin heavy-chain (Igh) loci undergo large-scale alterations in structure to facilitate juxtaposition and recombination of spatially separated variable (V(H)), diversity (D(H)), and joining (J(H)) genes. These chromosomal alterations are poorly unde...

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Detalles Bibliográficos
Autores principales: Mielczarek, Olga, Rogers, Carolyn H., Zhan, Yinxiu, Matheson, Louise S., Stubbington, Michael J.T., Schoenfelder, Stefan, Bolland, Daniel J., Javierre, Biola M., Wingett, Steven W., Várnai, Csilla, Segonds-Pichon, Anne, Conn, Simon J., Krueger, Felix, Andrews, Simon, Fraser, Peter, Giorgetti, Luca, Corcoran, Anne E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10548092/
https://www.ncbi.nlm.nih.gov/pubmed/37676766
http://dx.doi.org/10.1016/j.celrep.2023.113074

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10548092/
https://www.ncbi.nlm.nih.gov/pubmed/37676766
http://dx.doi.org/10.1016/j.celrep.2023.113074

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