Queuosine‐tRNA promotes sex‐dependent learning and memory formation by maintaining codon‐biased translation elongation speed

Queuosine (Q) is a modified nucleoside at the wobble position of specific tRNAs. In mammals, queuosinylation is facilitated by queuine uptake from the gut microbiota and is introduced into tRNA by the QTRT1‐QTRT2 enzyme complex. By establishing a Qtrt1 knockout mouse model, we discovered that the lo...

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Detalles Bibliográficos
Autores principales: Cirzi, Cansu, Dyckow, Julia, Legrand, Carine, Schott, Johanna, Guo, Wei, Perez Hernandez, Daniel, Hisaoka, Miharu, Parlato, Rosanna, Pitzer, Claudia, van der Hoeven, Franciscus, Dittmar, Gunnar, Helm, Mark, Stoecklin, Georg, Schirmer, Lucas, Lyko, Frank, Tuorto, Francesca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10548180/
https://www.ncbi.nlm.nih.gov/pubmed/37609797
http://dx.doi.org/10.15252/embj.2022112507

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10548180/
https://www.ncbi.nlm.nih.gov/pubmed/37609797
http://dx.doi.org/10.15252/embj.2022112507

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