Evolutionary adaptation from hydrolytic to oxygenolytic catalysis at the α/β-hydrolase fold

Protein fold adaptation to novel enzymatic reactions is a fundamental evolutionary process. Cofactor-independent oxygenases degrading N-heteroaromatic substrates belong to the α/β-hydrolase (ABH) fold superfamily that typically does not catalyze oxygenation reactions. Here, we have integrated crysta...

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Detalles Bibliográficos
Autores principales: Bui, Soi, Gil-Guerrero, Sara, van der Linden, Peter, Carpentier, Philippe, Ceccarelli, Matteo, Jambrina, Pablo G., Steiner, Roberto A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10548524/
https://www.ncbi.nlm.nih.gov/pubmed/37799987
http://dx.doi.org/10.1039/d3sc03044j

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10548524/
https://www.ncbi.nlm.nih.gov/pubmed/37799987
http://dx.doi.org/10.1039/d3sc03044j

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