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Evolutionary adaptation from hydrolytic to oxygenolytic catalysis at the α/β-hydrolase fold
Protein fold adaptation to novel enzymatic reactions is a fundamental evolutionary process. Cofactor-independent oxygenases degrading N-heteroaromatic substrates belong to the α/β-hydrolase (ABH) fold superfamily that typically does not catalyze oxygenation reactions. Here, we have integrated crysta...
Autores principales: | Bui, Soi, Gil-Guerrero, Sara, van der Linden, Peter, Carpentier, Philippe, Ceccarelli, Matteo, Jambrina, Pablo G., Steiner, Roberto A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10548524/ https://www.ncbi.nlm.nih.gov/pubmed/37799987 http://dx.doi.org/10.1039/d3sc03044j |
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