Cortistatin deficiency reveals a dysfunctional brain endothelium with impaired gene pathways, exacerbated immune activation, and disrupted barrier integrity

BACKGROUND: Brain activity governing cognition and behaviour depends on the fine-tuned microenvironment provided by a tightly controlled blood–brain barrier (BBB). Brain endothelium dysfunction is a hallmark of BBB breakdown in most neurodegenerative/neuroinflammatory disorders. Therefore, the ident...

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Detalles Bibliográficos
Autores principales: Castillo-González, Julia, Ruiz, José Luis, Serrano-Martínez, Ignacio, Forte-Lago, Irene, Ubago-Rodriguez, Ana, Caro, Marta, Pérez-Gómez, Jesús Miguel, Benítez-Troncoso, Alejandro, Andrés-León, Eduardo, Sánchez-Navarro, Macarena, Luque, Raúl M., González-Rey, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10548650/
https://www.ncbi.nlm.nih.gov/pubmed/37794493
http://dx.doi.org/10.1186/s12974-023-02908-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10548650/
https://www.ncbi.nlm.nih.gov/pubmed/37794493
http://dx.doi.org/10.1186/s12974-023-02908-5

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