Gut microbial metabolite deoxycholic acid facilitates Th17 differentiation through modulating cholesterol biosynthesis and participates in high-fat diet-associated colonic inflammation

BACKGROUND: High-fat diet (HFD) is closely associated with the increased prevalence of inflammatory bowel disease (IBD). Excessive gut microbial metabolite deoxycholic acid (DCA) caused by HFD plays significant roles in eliciting intestinal inflammation, however, the mechanism underlining the induct...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Dan, Zhou, Jiefei, Wang, Lingyu, Gong, Zizhen, Le, Huijuan, Huang, Ye, Xu, Congfeng, Tian, Chunyan, Cai, Wei, Wu, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10548658/
https://www.ncbi.nlm.nih.gov/pubmed/37789469
http://dx.doi.org/10.1186/s13578-023-01109-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10548658/
https://www.ncbi.nlm.nih.gov/pubmed/37789469
http://dx.doi.org/10.1186/s13578-023-01109-0

Ejemplares similares