Cargando…

Gut microbial metabolite deoxycholic acid facilitates Th17 differentiation through modulating cholesterol biosynthesis and participates in high-fat diet-associated colonic inflammation

BACKGROUND: High-fat diet (HFD) is closely associated with the increased prevalence of inflammatory bowel disease (IBD). Excessive gut microbial metabolite deoxycholic acid (DCA) caused by HFD plays significant roles in eliciting intestinal inflammation, however, the mechanism underlining the induct...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Dan, Zhou, Jiefei, Wang, Lingyu, Gong, Zizhen, Le, Huijuan, Huang, Ye, Xu, Congfeng, Tian, Chunyan, Cai, Wei, Wu, Jin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10548658/ https://www.ncbi.nlm.nih.gov/pubmed/37789469 http://dx.doi.org/10.1186/s13578-023-01109-0

Ejemplares similares

Deoxycholic Acid-Mediated Sphingosine-1-Phosphate Receptor 2 Signaling Exacerbates DSS-Induced Colitis through Promoting Cathepsin B Release
por: Zhao, Shengnan, et al.
Publicado: (2018)

Deoxycholic Acid Triggers NLRP3 Inflammasome Activation and Aggravates DSS-Induced Colitis in Mice
por: Zhao, Shengnan, et al.
Publicado: (2016)

Gut microbial bile acid metabolite skews macrophage polarization and contributes to high-fat diet-induced colonic inflammation
por: Wang, Lingyu, et al.
Publicado: (2020)

Microbial metabolite deoxycholic acid shapes microbiota against Campylobacter jejuni chicken colonization
por: Alrubaye, Bilal, et al.
Publicado: (2019)

Microbial metabolite deoxycholic acid promotes vasculogenic mimicry formation in intestinal carcinogenesis
por: Song, Xueli, et al.
Publicado: (2021)

Chenodeoxycholic acid activates NLRP3 inflammasome and contributes to cholestatic liver fibrosis
por: Gong, Zizhen, et al.
Publicado: (2016)

Microbial metabolite deoxycholic acid controls Clostridium perfringens-induced chicken necrotic enteritis through attenuating inflammatory cyclooxygenase signaling
por: Wang, Hong, et al.
Publicado: (2019)

Metabolic and Structural Effects of Phosphatidylcholine and Deoxycholate Injections on Subcutaneous Fat: A Randomized, Controlled Trial
por: Reeds, Dominic N., et al.
Publicado: (2013)

Lactate facilitates classical swine fever virus replication by enhancing cholesterol biosynthesis
por: Zou, Xiaodong, et al.
Publicado: (2022)

Commentary on: Metabolic and Structural Effects of Phosphatidylcholine and Deoxycholate Injections on Subcutaneous Fat: A Randomized, Controlled Trial
por: Duncan, Diane
Publicado: (2013)

Commentary on: Metabolic and Structural Effects of Phosphatidylcholine and Deoxycholate Injections on Subcutaneous Fat: A Randomized, Controlled Trial
por: Brown, Spencer A.
Publicado: (2013)

Identifying distinctive tissue and fecal microbial signatures and the tumor-promoting effects of deoxycholic acid on breast cancer
por: Wang, Na, et al.
Publicado: (2022)

Carcinogenicity of deoxycholate, a secondary bile acid
por: Bernstein, Carol, et al.
Publicado: (2011)

Deoxycholic Acid Injections for Bra-Line Lipolysis
por: Jegasothy, S. Manjula
Publicado: (2018)

Topical formulation of sodium deoxycholate for submental lipolysis
por: Park, Hye Jeong, et al.
Publicado: (2023)

Cholesterol sulfate alleviates ulcerative colitis by promoting cholesterol biosynthesis in colonic epithelial cells
por: Xu, Dongke, et al.
Publicado: (2022)

Facilitating Imaging Mass Spectrometry of Microbial Specialized Metabolites with METASPACE
por: Nguyen, Don D., et al.
Publicado: (2021)

Deoxycholic acid activates epidermal growth factor receptor and promotes intestinal carcinogenesis by ADAM17‐dependent ligand release
por: Dong, Wenxiao, et al.
Publicado: (2018)

Interaction of deoxycholate with the sodium channel of squid axon membranes
Publicado: (1980)

Deoxycholic acid supplementation impairs glucose homeostasis in mice
por: Zaborska, Karolina E., et al.
Publicado: (2018)

Research Note: Evaluation of deoxycholic acid for antihistomonal activity
por: Beer, L.C., et al.
Publicado: (2020)

Chronic Infection and Nodule Formation following Deoxycholate Injection
por: Shahid, Shahab, et al.
Publicado: (2022)

Biosynthesis of Cholesterol and Other Sterols
por: Nes, W. David
Publicado: (2011)

Microbial metabolite butyrate facilitates M2 macrophage polarization and function
por: Ji, Jian, et al.
Publicado: (2016)

Deoxycholate, an Endogenous Cytotoxin/Genotoxin, Induces the Autophagic Stress-Survival Pathway: Implications for Colon Carcinogenesis
por: Payne, Claire M., et al.
Publicado: (2009)

Cholecystectomy promotes colon carcinogenesis by activating the Wnt signaling pathway by increasing the deoxycholic acid level
por: Yao, Yuxia, et al.
Publicado: (2022)

Promotion of Deoxycholic Acid Effect on Colonic Cancer Cell Lines In Vitro by Altering the Mucosal Microbiota
por: Ma, Yanpeng, et al.
Publicado: (2022)

In Vitro Investigation of Self-Assembled Nanoparticles Based on Hyaluronic Acid-Deoxycholic Acid Conjugates for Controlled Release Doxorubicin: Effect of Degree of Substitution of Deoxycholic Acid
por: Wei, Wen-Hao, et al.
Publicado: (2015)

The 1β-Hydroxy-Deoxycholic Acid to Deoxycholic Acid Urinary Metabolic Ratio: Toward a Phenotyping of CYP3A Using an Endogenous Marker?
por: Magliocco, Gaëlle, et al.
Publicado: (2021)

Abstract 33: Localized Injection Site Alopecia in Male Patients After Treatment of Submental Fat with ATX-101 (Deoxycholic Acid)
por: Shridharani, Sachin M., et al.
Publicado: (2018)

The relationship between stool weight and the lithocholate/deoxycholate ratio in faeces.
por: Brydon, W. G., et al.
Publicado: (1988)

The cocarcinogenic effect of intrarectal deoxycholate in rats is reduced by oral metronidazole.
por: Rainey, J. B., et al.
Publicado: (1984)

Extracellular matrix in deoxycholic acid decellularized aortic heart valves
por: Bloch, Oliver, et al.
Publicado: (2012)

Acute hepatic injury with amphotericin B deoxycholate in an immunocompetent patient
por: Wagner, Jamie L., et al.
Publicado: (2016)

Injection Lipolysis with a Cocktail of Phosphatidylcholine and Deoxycholate: An Indian Experience
por: Thomas, Mohan, et al.
Publicado: (2016)

Piezogenic pedal papules treated successfully with deoxycholic acid injection
por: Turkmani, Mohammed G.
Publicado: (2018)

Enhanced Liver Targeting of Camptothecin via Conjugation with Deoxycholic Acid
por: Xiao, Linxia, et al.
Publicado: (2019)

Impact of deoxycholate on Clostridioides difficile growth, toxin production, and sporulation
por: Usui, Yukino, et al.
Publicado: (2020)

Effect of deoxycholate, amphotericin B and fongizone on transmissible gastroenteritis coronavirus
por: Nguyen, T.D., et al.
Publicado: (1987)

In vitro synergy between sodium deoxycholate and furazolidone against enterobacteria
por: Le, Vuong Van Hung, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_2o1bf7qco47bung9ne1i0g5cmc