Cystine/Glutamate antiporter system x(c)(-) deficiency impairs macrophage glutathione metabolism and cytokine production

System x(c)(-), encoded by Slc7a11, is an antiporter responsible for exporting glutamate while importing cystine, which is essential for protein synthesis and the formation of thiol peptides, such as glutathione. Glutathione acts as a co-factor for enzymes responsible for scavenging reactive oxygen...

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Detalles Bibliográficos
Autores principales: de Baat, Axel, Meier, Daniel T., Fontana, Adriano, Böni-Schnetzler, Marianne, Donath, Marc Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10550110/
https://www.ncbi.nlm.nih.gov/pubmed/37792774
http://dx.doi.org/10.1371/journal.pone.0291950

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10550110/
https://www.ncbi.nlm.nih.gov/pubmed/37792774
http://dx.doi.org/10.1371/journal.pone.0291950

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