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Cystine/Glutamate antiporter system x(c)(-) deficiency impairs macrophage glutathione metabolism and cytokine production
System x(c)(-), encoded by Slc7a11, is an antiporter responsible for exporting glutamate while importing cystine, which is essential for protein synthesis and the formation of thiol peptides, such as glutathione. Glutathione acts as a co-factor for enzymes responsible for scavenging reactive oxygen...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10550110/ https://www.ncbi.nlm.nih.gov/pubmed/37792774 http://dx.doi.org/10.1371/journal.pone.0291950 |