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CYP2C19 Genotype Prevalence and Association With Recurrent Myocardial Infarction in British–South Asians Treated With Clopidogrel

BACKGROUND: Cytochrome P450 family 2 subfamily C member 19 (CYP2C19) is a hepatic enzyme involved in the metabolism of clopidogrel from a prodrug to its active metabolite. Prior studies of genetic polymorphisms in CYP2C19 and their relationship with clinical efficacy have not included South Asian po...

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Detalles Bibliográficos
Autores principales: Magavern, Emma F., Jacobs, Benjamin, Warren, Helen, Finocchiaro, Gherardo, Finer, Sarah, van Heel, David A., Smedley, Damian, Caulfield, Mark J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10550831/
https://www.ncbi.nlm.nih.gov/pubmed/37808344
http://dx.doi.org/10.1016/j.jacadv.2023.100573