TET2 lesions enhance the aggressiveness of CEBPA-mutant acute myeloid leukemia by rebalancing GATA2 expression

The myeloid transcription factor CEBPA is recurrently biallelically mutated (i.e., double mutated; CEBPA(DM)) in acute myeloid leukemia (AML) with a combination of hypermorphic N-terminal mutations (CEBPA(NT)), promoting expression of the leukemia-associated p30 isoform, and amorphic C-terminal muta...

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Detalles Bibliográficos
Autores principales: Heyes, Elizabeth, Wilhelmson, Anna S., Wenzel, Anne, Manhart, Gabriele, Eder, Thomas, Schuster, Mikkel B., Rzepa, Edwin, Pundhir, Sachin, D’Altri, Teresa, Frank, Anne-Katrine, Gentil, Coline, Woessmann, Jakob, Schoof, Erwin M., Meggendorfer, Manja, Schwaller, Jürg, Haferlach, Torsten, Grebien, Florian, Porse, Bo T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10550934/
https://www.ncbi.nlm.nih.gov/pubmed/37794021
http://dx.doi.org/10.1038/s41467-023-41927-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10550934/
https://www.ncbi.nlm.nih.gov/pubmed/37794021
http://dx.doi.org/10.1038/s41467-023-41927-x

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