Cargando…

Structural mechanisms of the human cardiac sodium-calcium exchanger NCX1

Na(+)/Ca(2+) exchangers (NCX) transport Ca(2+) in or out of cells in exchange for Na(+). They are ubiquitously expressed and play an essential role in maintaining cytosolic Ca(2+) homeostasis. Although extensively studied, little is known about the global structural arrangement of eukaryotic NCXs an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xue, Jing, Zeng, Weizhong, Han, Yan, John, Scott, Ottolia, Michela, Jiang, Youxing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10550945/ https://www.ncbi.nlm.nih.gov/pubmed/37794011 http://dx.doi.org/10.1038/s41467-023-41885-4

Ejemplares similares

Structure-Functional Basis of Ion Transport in Sodium–Calcium Exchanger (NCX) Proteins
por: Giladi, Moshe, et al.
Publicado: (2016)

Calmodulin Interacts with the Sodium/Calcium Exchanger NCX1 to Regulate Activity
por: Chou, Ai-Chuan, et al.
Publicado: (2015)

Structural Features of Ion Transport and Allosteric Regulation in Sodium-Calcium Exchanger (NCX) Proteins
por: Giladi, Moshe, et al.
Publicado: (2016)

Structure-based dynamic arrays in regulatory domains of sodium-calcium exchanger (NCX) isoforms
por: Giladi, Moshe, et al.
Publicado: (2017)

The Effect of a Novel Highly Selective Inhibitor of the Sodium/Calcium Exchanger (NCX) on Cardiac Arrhythmias in In Vitro and In Vivo Experiments
por: Kohajda, Zsófia, et al.
Publicado: (2016)

NCX-DB: a unified resource for integrative analysis of the sodium calcium exchanger super-family
por: Bode, Katrin, et al.
Publicado: (2018)

Acute Genetic Ablation of Cardiac Sodium/Calcium Exchange in Adult Mice: Implications for Cardiomyocyte Calcium Regulation, Cardioprotection, and Arrhythmia
por: Lotteau, Sabine, et al.
Publicado: (2021)

Mechanism of extracellular ion exchange and binding-site occlusion in the sodium-calcium exchanger
por: Liao, Jun, et al.
Publicado: (2016)

Carbon nanotube promotes contraction and electrical activity of neonatal cardiomyocytes by targeting sodium/calcium exchanger NCX1
por: Zhang, Xiao, et al.
Publicado: (2023)

Development of a high-affinity peptide that prevents phospholemman (PLM) inhibition of the sodium/calcium exchanger 1 (NCX1)
por: Wanichawan, Pimthanya, et al.
Publicado: (2016)

Structural mechanism of allosteric activation of TRPML1 by PI(3,5)P(2) and rapamycin
por: Gan, Ninghai, et al.
Publicado: (2022)

Gene Structure Evolution of the Na(+)-Ca(2+ )Exchanger (NCX) Family
por: On, Caly, et al.
Publicado: (2008)

Electrophysiological characterization of the archaeal transporter NCX_Mj using solid supported membrane technology
por: Barthmes, Maria, et al.
Publicado: (2016)

Molecular determinants of pH regulation in the cardiac Na(+)–Ca(2+) exchanger
por: John, Scott, et al.
Publicado: (2018)

Structures of the Calcium-activated Non-Selective Cation Channel TRPM4
por: Guo, Jiangtao, et al.
Publicado: (2017)

Role of Na(+)/Ca(2+) Exchanger (NCX) in Modulating Postovulatory Aging of Mouse and Rat Oocytes
por: Zhang, Chuan-Xin, et al.
Publicado: (2014)

Role of Na(+)/Ca(2+) Exchanger (NCX) in Glioblastoma Cell Migration (In Vitro)
por: Brandalise, Federico, et al.
Publicado: (2023)

Sodium-calcium exchange /
Publicado: (1991)

Sodium-calcium exchange /
Publicado: (1989)

Sodium and potassium competition in potassium-selective and non-selective channels
por: Sauer, David B., et al.
Publicado: (2013)

Sodium-calcium exchange in regulation of cardiac contractility. Evidence for an electrogenic, voltage-dependent mechanism
Publicado: (1979)

Transport and Regulation of the Cardiac Na(+)-Ca(2+) Exchanger, NCX1 : Comparison between Ca(2+) and Ba(2+)
por: Trac, Michael, et al.
Publicado: (1997)

Cryo-EM structures of human ZnT8 in both outward- and inward-facing conformations
por: Xue, Jing, et al.
Publicado: (2020)

Cloning, Expression, and Characterization of the Squid Na(+)–Ca(2+) Exchanger (NCX-SQ1)
por: He, Zhaoping, et al.
Publicado: (1998)

Suppressing Effect of Na(+)/Ca(2+) Exchanger (NCX) Inhibitors on the Growth of Melanoma Cells
por: Liu, Zikai, et al.
Publicado: (2022)

Cryo-EM structure of the mitochondrial calcium uniporter
por: Nguyen, Nam X., et al.
Publicado: (2018)

Steady-state and dynamic properties of cardiac sodium-calcium exchange. Sodium-dependent inactivation
Publicado: (1992)

Essential role of the Na(+)-Ca2(+) exchanger (NCX) in glutamate-enhanced cell survival in cardiac cells exposed to hypoxia/reoxygenation
por: Maiolino, Marta, et al.
Publicado: (2017)

Structural mechanisms of phospholipid activation of the human TPC2 channel
por: She, Ji, et al.
Publicado: (2019)

Gene Expression Profiling Elucidates Cellular Responses to NCX4040 in Human Ovarian Tumor Cells: Implications in the Mechanisms of Action of NCX4040
por: Sinha, Birandra K., et al.
Publicado: (2022)

The precursor osteoblast-like cell, MC3T3-E1 cell line, enhances sodium–calcium exchanger 1 (Ncx1) gene expression by stretch stimuli prior to osteoblast differentiation
por: WARITA, Katsuhiko, et al.
Publicado: (2019)

The context-dependent role of the Na(+)/Ca(2+)-exchanger (NCX) in pancreatic stellate cell migration
por: Loeck, Thorsten, et al.
Publicado: (2023)

Calcium Microdomain Formation at the Perisynaptic Cradle Due to NCX Reversal: A Computational Study
por: Wade, John Joseph, et al.
Publicado: (2019)

NCX1 represents an ionic Na(+) sensing mechanism in macrophages
por: Neubert, Patrick, et al.
Publicado: (2020)

Structure-Based Function and Regulation of NCX Variants: Updates and Challenges
por: Khananshvili, Daniel
Publicado: (2022)

Role of Sodium/Calcium Exchangers in Tumors
por: Chovancova, Barbora, et al.
Publicado: (2020)

Ionic Regulatory Properties of Brain and Kidney Splice Variants of the Ncx1 Na(+)–Ca(2+) Exchanger
por: Dyck, Chris, et al.
Publicado: (1999)

The role of stretch, tachycardia and sodium‐calcium exchanger in induction of early cardiac remodelling
por: Djalinac, Natasa, et al.
Publicado: (2020)

Blockade of sodium‑calcium exchanger via ORM-10962 attenuates cardiac alternans
por: Szlovák, Jozefina, et al.
Publicado: (2021)

The topology of the C-terminal sections of the NCX1 Na(+)/Ca(2+) exchanger and the NCKX2 Na(+)/Ca(2+)-K(+) exchanger
por: Szerencsei, Robert T., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_2mnhgjqpg7mokkj6hd07qepkhm