Pulmonary exacerbations in early cystic fibrosis lung disease are marked by strong modulation of CD3 and PD-1 on luminal T cells

BACKGROUND: In chronic cystic fibrosis (CF) lung disease, neutrophilic inflammation and T-cell inhibition occur concomitantly, partly due to neutrophil-mediated release of the T-cell inhibitory enzyme Arg1. However, the onset of this tonic inhibition of T cells, and the impact of pulmonary exacerbat...

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Detalles Bibliográficos
Autores principales: Giacalone, Vincent D., Giraldo, Diego Moncada, Silva, George L., Hosten, Justin, Peng, Limin, Guglani, Lokesh, Tirouvanziam, Rabindra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10551126/
https://www.ncbi.nlm.nih.gov/pubmed/37809107
http://dx.doi.org/10.3389/fimmu.2023.1194253

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10551126/
https://www.ncbi.nlm.nih.gov/pubmed/37809107
http://dx.doi.org/10.3389/fimmu.2023.1194253

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