Cargando…

IL-21/23 axis modulates inflammatory cytokines and RANKL expression in RA CD4(+) T cells via p-Akt1 signaling

INTRODUCTION: CD4(+) T cells are critically involved in the pathogenesis of Rheumatoid Arthritis; an autoimmune disorder characterized by joint inflammation and bone degeneration. In this study, we focused on the critical role of cytokines, IL-21 and IL-23 in facilitating the aberrant status of RA T...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bhattacharya, Gargee, Sengupta, Soumya, Jha, Rohila, Shaw, Shubham K., Jogdand, Gajendra M., Barik, Prakash K., Padhan, Prasanta, Parida, Jyoti R., Devadas, Satish
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10551441/ https://www.ncbi.nlm.nih.gov/pubmed/37809066 http://dx.doi.org/10.3389/fimmu.2023.1235514

Ejemplares similares

IL-21, Inflammatory Cytokines and Hyperpolarized CD8(+) T Cells Are Central Players in Lupus Immune Pathology
por: Sengupta, Soumya, et al.
Publicado: (2023)

Inducible Costimulator Expressing T Cells Promote Parasitic Growth During Blood Stage Plasmodium berghei ANKA Infection
por: Jogdand, Gajendra M., et al.
Publicado: (2018)

Underlying Co-Morbidity Reveals Unique Immune Signatures in Type II Diabetes Patients Infected With SARS-CoV2
por: Sengupta, Soumya, et al.
Publicado: (2022)

Regulators of Tfh Cell Differentiation
por: Jogdand, Gajendra M., et al.
Publicado: (2016)

iCa(2+) Flux, ROS and IL-10 Determines Cytotoxic, and Suppressor T Cell Functions in Chronic Human Viral Infections
por: Mohanty, Subhasmita, et al.
Publicado: (2020)

Inherent low Erk and p38 activity reduce Fas Ligand expression and degranulation in T helper 17 cells leading to activation induced cell death resistance
por: Peroumal, Doureradjou, et al.
Publicado: (2016)

Clinical, Virological, Immunological, and Genomic Characterization of Asymptomatic and Symptomatic Cases With SARS-CoV-2 Infection in India
por: Chatterjee, Sanchari, et al.
Publicado: (2021)

Single-Cell Immunogenomic Approach Identified SARS-CoV-2 Protective Immune Signatures in Asymptomatic Direct Contacts of COVID-19 Cases
por: Sen, Kaushik, et al.
Publicado: (2021)

RANK and RANKL expression in RA synovium and lymph nodes as markers of dendritic cell-T cell interactions
por: Page, G, et al.
Publicado: (2004)

ETS1 polymorphism rs73013527 in relation to serum RANKL levels among patients with RA
por: Yang, Bin, et al.
Publicado: (2021)

Genetic association of IL2RA, IL17RA, IL23R, and IL31RA single nucleotide polymorphisms with alopecia areata
por: Alghamdi, Mansour A., et al.
Publicado: (2022)

Sinomenine Suppresses Osteoclast Formation and Mycobacterium tuberculosis H37Ra-Induced Bone Loss by Modulating RANKL Signaling Pathways
por: Li, Xiaojuan, et al.
Publicado: (2013)

Inhibition of RANKL-Induced Osteoclastogenesis by Novel Mutant RANKL
por: Jang, Yuria, et al.
Publicado: (2021)

Comment on: Incidence of ocular and systemic diseases affecting visual function among state bus drivers
por: Rohila, Jyoti, et al.
Publicado: (2022)

Comments on: Association of near work and dim light with myopia among 1400 school children in a district in North India
por: Bhatia, Anuradha, et al.
Publicado: (2023)

An Overview of the Extraarticular Involvement in Rheumatoid Arthritis and its Management
por: Das, Subham, et al.
Publicado: (2017)

Splenic Calcification in a Case of Sarcoidosis
por: Padhan, Prasanta, et al.
Publicado: (2021)

Tuberous xanthomas mimicking tophaceous gout
por: Dhanawat, Aditya, et al.
Publicado: (2020)

Skeletal Fluorosis Mimicking Spondyloarthritis: A Rare Presentation
por: Padhan, Prasanta, et al.
Publicado: (2022)

Effect of low dose methotrexate as an add-on therapy in patients with palindromic rheumatism unresponsive to hydroxychloroquine: An observational study
por: Padhan, Prasanta, et al.
Publicado: (2021)

Trigeminal Neuralgia as an Initial Presentation of Systemic Autoimmune Diseases: A Case Series
por: Maikap, Debashis, et al.
Publicado: (2022)

Serum RANKL, osteoprotegerin (OPG), and RANKL/OPG ratio in nephrotic children
por: Wasilewska, Anna, et al.
Publicado: (2010)

From discovery of RANKL to clinical application of anti-human RANKL antibody
por: Yasuda, Hisataka, et al.
Publicado: (2012)

RANKL Expression in Periodontal Disease: Where Does RANKL Come from?
por: Chen, Bin, et al.
Publicado: (2014)

Inverse behavior of IL-23R and IL-17RA in chronic and aggressive periodontitis
por: del Carmen Ruíz-Gutiérrez, Alondra, et al.
Publicado: (2021)

Targeting RANKL in metastasis
por: Dougall, William C, et al.
Publicado: (2014)

Outcome of rheumatoid arthritis following adjunct statin therapy
por: Das, Subham, et al.
Publicado: (2015)

Successful Use of Tofacitinib in Scleroderma Arthropathy
por: MV, Prakashini, et al.
Publicado: (2023)

Successful Use of Tofacitinib in Refractory Takayasu Arteritis: A Case Series
por: MV, Prakashini, et al.
Publicado: (2023)

Striatal Hand Deformity in Parkinson’s Disease Mimicking Rheumatoid Arthritis
por: Maikap, Debashis, et al.
Publicado: (2023)

The Protective Effects of IL-31RA Deficiency During Bleomycin-Induced Pulmonary Fibrosis
por: Yombo, Dan J. K., et al.
Publicado: (2021)

Circulating RANKL is inversely related to RANKL mRNA levels in bone in osteoarthritic males
por: Findlay, David, et al.
Publicado: (2008)

Association of salivary RANKL and osteoprotegerin levels with periodontal health
por: Ochanji, A. A., et al.
Publicado: (2017)

A Synthetic Peptide, CK2.3, Inhibits RANKL-Induced Osteoclastogenesis through BMPRIa and ERK Signaling Pathway
por: Nguyen, John, et al.
Publicado: (2020)

The Cytoplasmic Dynein Associated Protein NDE1 Regulates Osteoclastogenesis by Modulating M-CSF and RANKL Signaling Pathways
por: Das, Bhaba K., et al.
Publicado: (2021)

Biology of RANK, RANKL, and osteoprotegerin
por: Boyce, Brendan F, et al.
Publicado: (2007)

Role of RANKL inhibition in osteoporosis
por: McClung, Michael
Publicado: (2007)

RANK–RANKL signalling in cancer
por: Renema, Nathalie, et al.
Publicado: (2016)

The importance of cell surface RANKL in rheumatoid arthritis
por: Krystufkova, O, et al.
Publicado: (2005)

Investigation of $\alpha$-decay rates of $^{221}$Fr, $^{224}$Ra and $^{226}$Ra in different environments.
por: Jeppesen, H B, et al.
Publicado: (2006)

Cannot write session to /tmp/vufind_sessions/sess_eefa1hgb7dg63hressqsffg4gj