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Misregulation of cell cycle-dependent methylation of budding yeast CENP-A contributes to chromosomal instability

Centromere (CEN) identity is specified epigenetically by specialized nucleosomes containing evolutionarily conserved CEN-specific histone H3 variant CENP-A (Cse4 in Saccharomyces cerevisiae, CENP-A in humans), which is essential for faithful chromosome segregation. However, the epigenetic mechanisms...

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Detalles Bibliográficos
Autores principales: Mishra, Prashant K., Au, Wei-Chun, Castineira, Pedro G., Ali, Nazrin, Stanton, John, Boeckmann, Lars, Takahashi, Yoshimitsu, Costanzo, Michael, Boone, Charles, Bloom, Kerry S., Thorpe, Peter H., Basrai, Munira A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10551700/
https://www.ncbi.nlm.nih.gov/pubmed/37436802
http://dx.doi.org/10.1091/mbc.E23-03-0108