The unfolded protein response of the endoplasmic reticulum supports mitochondrial biogenesis by buffering nonimported proteins

Almost all mitochondrial proteins are synthesized in the cytosol and subsequently targeted to mitochondria. The accumulation of nonimported precursor proteins occurring upon mitochondrial dysfunction can challenge cellular protein homeostasis. Here we show that blocking protein translocation into mi...

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Detalles Bibliográficos
Autores principales: Knöringer, Katharina, Groh, Carina, Krämer, Lena, Stein, Kevin C., Hansen, Katja G., Zimmermann, Jannik, Morgan, Bruce, Herrmann, Johannes M., Frydman, Judith, Boos, Felix
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2023
Materias:
Special Issue on Protein Quality Control
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10551703/
https://www.ncbi.nlm.nih.gov/pubmed/37379206
http://dx.doi.org/10.1091/mbc.E23-05-0205

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10551703/
https://www.ncbi.nlm.nih.gov/pubmed/37379206
http://dx.doi.org/10.1091/mbc.E23-05-0205

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