Matriptase-2 regulates iron homeostasis primarily by setting the basal levels of hepatic hepcidin expression through a nonproteolytic mechanism

Matriptase-2 (MT2), encoded by TMPRSS6, is a membrane-anchored serine protease. It plays a key role in iron homeostasis by suppressing the iron-regulatory hormone, hepcidin. Lack of functional MT2 results in an inappropriately high hepcidin and iron-refractory iron-deficiency anemia. Mt2 cleaves mul...

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Detalles Bibliográficos
Autores principales: Enns, Caroline A., Weiskopf, Tyler, Zhang, Richard H., Wu, Jeffrey, Jue, Shall, Kawaguchi, Makiko, Kataoka, Hiroaki, Zhang, An-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10551898/
https://www.ncbi.nlm.nih.gov/pubmed/37690687
http://dx.doi.org/10.1016/j.jbc.2023.105238

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10551898/
https://www.ncbi.nlm.nih.gov/pubmed/37690687
http://dx.doi.org/10.1016/j.jbc.2023.105238

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