Cargando…
15-keto-PGE(2) alleviates nonalcoholic steatohepatitis through its covalent modification of NF-κB factors
15-keto-PGE(2) is one of the eicosanoids with anti-inflammatory properties. In this study, we demonstrated that 15-keto-PGE(2) post-translationally modified the nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) subunits p105/p50 and p65 at Cys59 and Cys120 sites, respectively, hence...
Autores principales: | Hee, Siow-Wey, Chang, Yi-Cheng, Su, Lynn, Chen, Ing-Jung, Jeng, Yung-Ming, Hsieh, Meng-Lun, Chang, Yu-Chia, Li, Fu-An, Liao, Daniel, Chen, Shiau-Mei, Chuang, Lee-Ming |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10551900/ https://www.ncbi.nlm.nih.gov/pubmed/37810249 http://dx.doi.org/10.1016/j.isci.2023.107997 |
Ejemplares similares
-
Inhibition of Prostaglandin Reductase 2, a Putative Oncogene Overexpressed in Human Pancreatic Adenocarcinoma, Induces Oxidative Stress-Mediated Cell Death Involving xCT and CTH Gene Expressions through 15-Keto-PGE(2)
por: Chang, Emily Yun-Chia, et al.
Publicado: (2016) -
The Role of Organelle Stresses in Diabetes Mellitus and Obesity: Implication for Treatment
por: Chang, Yi-Cheng, et al.
Publicado: (2015) -
Hyperuricemia Inversely Correlates with Disease Severity in Taiwanese Nonalcoholic Steatohepatitis Patients
por: Huang, Jee-Fu, et al.
Publicado: (2015) -
Overexpression of Hepcidin Alleviates Steatohepatitis and Fibrosis in a Diet-induced Nonalcoholic Steatohepatitis
por: Chen, Hui, et al.
Publicado: (2022) -
Discovery of a natural small-molecule AMP-activated kinase activator that alleviates nonalcoholic steatohepatitis
por: Chen, Jin, et al.
Publicado: (2023)