PheWAS and cross-disorder analysis reveal genetic architecture, pleiotropic loci and phenotypic correlations across 11 autoimmune disorders

INTRODUCTION: Autoimmune disorders (ADs) are a group of about 80 disorders that occur when self-attacking autoantibodies are produced due to failure in the self-tolerance mechanisms. ADs are polygenic disorders and associations with genes both in the human leukocyte antigen (HLA) region and outside...

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Detalles Bibliográficos
Autores principales: Topaloudi, Apostolia, Jain, Pritesh, Martinez, Melanie B., Bryant, Josephine K., Reynolds, Grace, Zagoriti, Zoi, Lagoumintzis, George, Zamba-Papanicolaou, Eleni, Tzartos, John, Poulas, Konstantinos, Kleopa, Kleopas A., Tzartos, Socrates, Georgitsi, Marianthi, Drineas, Petros, Paschou, Peristera
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10552152/
https://www.ncbi.nlm.nih.gov/pubmed/37809097
http://dx.doi.org/10.3389/fimmu.2023.1147573

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10552152/
https://www.ncbi.nlm.nih.gov/pubmed/37809097
http://dx.doi.org/10.3389/fimmu.2023.1147573

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