MCProj: metacell projection for interpretable and quantitative use of transcriptional atlases

We describe MCProj—an algorithm for analyzing query scRNA-seq data by projections over reference single-cell atlases. We represent the reference as a manifold of annotated metacell gene expression distributions. We then interpret query metacells as mixtures of atlas distributions while correcting fo...

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Detalles Bibliográficos
Autores principales: Ben-Kiki, Oren, Bercovich, Akhiad, Lifshitz, Aviezer, Raz, Ofir, Brook, Dror, Tanay, Amos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10552220/
https://www.ncbi.nlm.nih.gov/pubmed/37798781
http://dx.doi.org/10.1186/s13059-023-03069-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10552220/
https://www.ncbi.nlm.nih.gov/pubmed/37798781
http://dx.doi.org/10.1186/s13059-023-03069-7

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