Cryo-EM structures of tau filaments from the brains of mice transgenic for human mutant P301S Tau

Mice transgenic for human mutant P301S tau are widely used as models for human tauopathies. They develop neurodegeneration and abundant filamentous inclusions made of human mutant four-repeat tau. Here we used electron cryo-microscopy (cryo-EM) to determine the structures of tau filaments from the b...

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Detalles Bibliográficos
Autores principales: Schweighauser, Manuel, Murzin, Alexey G., Macdonald, Jennifer, Lavenir, Isabelle, Crowther, R. Anthony, Scheres, Sjors H.W., Goedert, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10552433/
https://www.ncbi.nlm.nih.gov/pubmed/37798679
http://dx.doi.org/10.1186/s40478-023-01658-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10552433/
https://www.ncbi.nlm.nih.gov/pubmed/37798679
http://dx.doi.org/10.1186/s40478-023-01658-y

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