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Cryo-EM structures of tau filaments from the brains of mice transgenic for human mutant P301S Tau
Mice transgenic for human mutant P301S tau are widely used as models for human tauopathies. They develop neurodegeneration and abundant filamentous inclusions made of human mutant four-repeat tau. Here we used electron cryo-microscopy (cryo-EM) to determine the structures of tau filaments from the b...
Autores principales: | Schweighauser, Manuel, Murzin, Alexey G., Macdonald, Jennifer, Lavenir, Isabelle, Crowther, R. Anthony, Scheres, Sjors H.W., Goedert, Michel |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10552433/ https://www.ncbi.nlm.nih.gov/pubmed/37798679 http://dx.doi.org/10.1186/s40478-023-01658-y |
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