Inhibition of the RNA-Dependent RNA-Polymerase from SARS-CoV-2 by 6-Chloropurine Isoxazoline-Carbocyclic Monophosphate Nucleotides

[Image: see text] Isoxazoline-carbocyclic monophosphate nucleotides were designed and synthesized through the chemistry of nitrosocarbonyl intermediates and stable anthracenenitrile oxide. Docking and molecular dynamics studies were first conducted for determining the best candidate for polymerase S...

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Detalles Bibliográficos
Autores principales: Leusciatti, Marco, Macchi, Beatrice, Marino-Merlo, Francesca, Mastino, Antonio, Morra, Giulia, Quadrelli, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10552509/
https://www.ncbi.nlm.nih.gov/pubmed/37810686
http://dx.doi.org/10.1021/acsomega.3c04918

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10552509/
https://www.ncbi.nlm.nih.gov/pubmed/37810686
http://dx.doi.org/10.1021/acsomega.3c04918

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