Isocitrate dehydrogenase 1 sustains a hybrid cytoplasmic–mitochondrial tricarboxylic acid cycle that can be targeted for therapeutic purposes in prostate cancer

The androgen receptor (AR) is an established orchestrator of cell metabolism in prostate cancer (PCa), notably by inducing an oxidative mitochondrial program. Intriguingly, AR regulates cytoplasmic isocitrate dehydrogenase 1 (IDH1), but not its mitochondrial counterparts IDH2 and IDH3. Here, we aime...

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Detalles Bibliográficos
Autores principales: Gonthier, Kevin, Weidmann, Cindy, Berthiaume, Line, Jobin, Cynthia, Lacouture, Aurélie, Lafront, Camille, Harvey, Mario, Neveu, Bertrand, Loehr, Jérémy, Bergeron, Alain, Fradet, Yves, Lacombe, Louis, Riopel, Julie, Latulippe, Éva, Atallah, Chantal, Shum, Michael, Lambert, Jean‐Philippe, Pouliot, Frédéric, Pelletier, Martin, Audet‐Walsh, Étienne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10552900/
https://www.ncbi.nlm.nih.gov/pubmed/37086156
http://dx.doi.org/10.1002/1878-0261.13441

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10552900/
https://www.ncbi.nlm.nih.gov/pubmed/37086156
http://dx.doi.org/10.1002/1878-0261.13441

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