Cargando…

Isocitrate dehydrogenase 1 sustains a hybrid cytoplasmic–mitochondrial tricarboxylic acid cycle that can be targeted for therapeutic purposes in prostate cancer

The androgen receptor (AR) is an established orchestrator of cell metabolism in prostate cancer (PCa), notably by inducing an oxidative mitochondrial program. Intriguingly, AR regulates cytoplasmic isocitrate dehydrogenase 1 (IDH1), but not its mitochondrial counterparts IDH2 and IDH3. Here, we aime...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gonthier, Kevin, Weidmann, Cindy, Berthiaume, Line, Jobin, Cynthia, Lacouture, Aurélie, Lafront, Camille, Harvey, Mario, Neveu, Bertrand, Loehr, Jérémy, Bergeron, Alain, Fradet, Yves, Lacombe, Louis, Riopel, Julie, Latulippe, Éva, Atallah, Chantal, Shum, Michael, Lambert, Jean‐Philippe, Pouliot, Frédéric, Pelletier, Martin, Audet‐Walsh, Étienne
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10552900/ https://www.ncbi.nlm.nih.gov/pubmed/37086156 http://dx.doi.org/10.1002/1878-0261.13441

Ejemplares similares

Multiple metabolic pathways fuel the truncated tricarboxylic acid cycle of the prostate to sustain constant citrate production and secretion
por: Frégeau-Proulx, Lilianne, et al.
Publicado: (2022)

A FACS-Free Purification Method to Study Estrogen Signaling, Organoid Formation, and Metabolic Reprogramming in Mammary Epithelial Cells
por: Lacouture, Aurélie, et al.
Publicado: (2021)

A Systematic Study of the Impact of Estrogens and Selective Estrogen Receptor Modulators on Prostate Cancer Cell Proliferation
por: Lafront, Camille, et al.
Publicado: (2020)

FACS-Free isolation and purification protocol of mouse prostate epithelial cells for organoid primary culture
por: Frégeau-Proulx, Lilianne, et al.
Publicado: (2022)

Subversion of infiltrating prostate macrophages to a mixed immunosuppressive tumor‐associated macrophage phenotype
por: Boibessot, Clovis, et al.
Publicado: (2022)

A transcriptional biosensor to monitor single cancer cell therapeutic responses by bioluminescence microscopy
por: Champagne, Audrey, et al.
Publicado: (2022)

A PCA3 gene-based transcriptional amplification system targeting primary prostate cancer
por: Neveu, Bertrand, et al.
Publicado: (2015)

Corrigendum: Bioluminescence Microscopy as a Method to Measure Single Cell Androgen Receptor Activity Heterogeneous Responses to Antiandrogens
por: Jain, Pallavi, et al.
Publicado: (2016)

Bioluminescence Microscopy as a Method to Measure Single Cell Androgen Receptor Activity Heterogeneous Responses to Antiandrogens
por: Jain, Pallavi, et al.
Publicado: (2016)

Effects of omega‐3 supplementation on psychological symptoms in men with prostate cancer: Secondary analysis of a double‐blind placebo‐controlled randomized trial
por: Savard, Josée, et al.
Publicado: (2023)

IL-8 secretion in primary cultures of prostate cells is associated with prostate cancer aggressiveness
por: Neveu, Bertrand, et al.
Publicado: (2014)

Mutation of Isocitrate Dehydrogenase 1 in Cholangiocarcinoma Impairs Tumor Progression by Inhibiting Isocitrate Metabolism
por: Su, Li, et al.
Publicado: (2020)

A Nutrient-Based Cellular Model to Characterize Acetylation-Dependent Protein-Protein Interactions
por: Loehr, Jérémy, et al.
Publicado: (2022)

Branched Tricarboxylic Acid Metabolism in Plasmodium falciparum
por: Olszewski, Kellen L., et al.
Publicado: (2010)

Regulation and function of the mammalian tricarboxylic acid cycle
por: Arnold, Paige K., et al.
Publicado: (2022)

Is there an impact of feet position on squatting birth position? An innovative biomechanical pilot study
por: Desseauve, David, et al.
Publicado: (2019)

FDG-PET/CT for pre-operative staging and prognostic stratification of patients with high-grade prostate cancer at biopsy
por: Beauregard, Jean-Mathieu, et al.
Publicado: (2015)

High infiltration of CD209(+) dendritic cells and CD163(+) macrophages in the peritumor area of prostate cancer is predictive of late adverse outcomes
por: Molina, Oscar Eduardo, et al.
Publicado: (2023)

Allogeneic dendritic cells stimulated with antibodies against HLA class II polarize naive T cells in a follicular helper phenotype
por: Désy, Olivier, et al.
Publicado: (2018)

The Role of Tricarboxylic Acid Cycle Metabolites in Viral Infections
por: Sánchez-García, Francisco Javier, et al.
Publicado: (2021)

Involvement of Tricarboxylic Acid Cycle Metabolites in Kidney Diseases
por: Jiménez-Uribe, Alexis Paulina, et al.
Publicado: (2021)

Optical Properties of Tricarboxylic Acid-Derived Carbon Dots
por: Tomskaya, Aleksandra, et al.
Publicado: (2022)

Isocitrate dehydrogenase mutations in myeloid malignancies
por: Medeiros, B C, et al.
Publicado: (2017)

Identification of Noise Covariance Matrices to Improve Orientation Estimation by Kalman Filter
por: Nez, Alexis, et al.
Publicado: (2018)

Elongated and substituted triazine-based tricarboxylic acid linkers for MOFs
por: Klinkebiel, Arne, et al.
Publicado: (2016)

Tricarboxylates Induce Defense Priming Against Bacteria in Arabidopsis thaliana
por: Balmer, Andrea, et al.
Publicado: (2018)

Tricarboxylic Acid (TCA) Cycle Intermediates: Regulators of Immune Responses
por: Choi, Inseok, et al.
Publicado: (2021)

Signals from the Circle: Tricarboxylic Acid Cycle Intermediates as Myometabokines
por: Maurer, Jennifer, et al.
Publicado: (2021)

Systemic alterations of tricarboxylic acid cycle enzymes in Alzheimer’s disease
por: Jia, Dongdong, et al.
Publicado: (2023)

Isocitrate dehydrogenase inhibitors in acute myeloid leukemia
por: Liu, Xiaoyan, et al.
Publicado: (2019)

The Role of Isocitrate Dehydrogenases in Direct Reprogramming to Cardiomyocytes
por: Ishida, Tomoaki, et al.
Publicado: (2021)

Isocitrate protects DJ-1 null dopaminergic cells from oxidative stress through NADP(+)-dependent isocitrate dehydrogenase (IDH)
por: Yang, Jinsung, et al.
Publicado: (2017)

Reduced tricarboxylic acid cycle flux in type 2 diabetes mellitus?
por: Schrauwen, P., et al.
Publicado: (2008)

The Tricarboxylic Acid Cycle, an Ancient Metabolic Network with a Novel Twist
por: Mailloux, Ryan J., et al.
Publicado: (2007)

Rapid determination of tricarboxylic acid cycle enzyme activities in biological samples
por: Goncalves, Sergio, et al.
Publicado: (2010)

Evolution and Functional Implications of the Tricarboxylic Acid Cycle as Revealed by Phylogenetic Analysis
por: Cavalcanti, João Henrique Frota, et al.
Publicado: (2014)

Protein-protein interactions and metabolite channelling in the plant tricarboxylic acid cycle
por: Zhang, Youjun, et al.
Publicado: (2017)

Breaking the cycle: Reversal of flux in the tricarboxylic acid cycle by dimethyl fumarate
por: Gafson, Arie R., et al.
Publicado: (2019)

Therapeutic potential of tricarboxylic acid cycle metabolite itaconate in cardiovascular diseases
por: Yang, Chongzhe, et al.
Publicado: (2020)

Stochastic Variation in Expression of the Tricarboxylic Acid Cycle Produces Persister Cells
por: Zalis, Eliza A., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_cnvl131212gd2dhv8bd4uhbbem