Long term survival and abnormal liver fat accumulation in mice with specific thymidine kinase 2 deficiency in liver tissue

Deficiency in thymidine kinase 2 (TK2) causes mitochondrial DNA depletion. Liver mitochondria are severely affected in Tk2 complete knockout models and have been suggested to play a role in the pathogenesis of the Tk2 knockout phenotype, characterized by loss of hypodermal fat tissue, growth retarda...

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Detalles Bibliográficos
Autores principales: Zhao, Qian, Zhou, Xiaoshan, Yan, Jingyi, Kuiper, Raoul, Curbo, Sophie, Karlsson, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10553353/
https://www.ncbi.nlm.nih.gov/pubmed/37796969
http://dx.doi.org/10.1371/journal.pone.0285242

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10553353/
https://www.ncbi.nlm.nih.gov/pubmed/37796969
http://dx.doi.org/10.1371/journal.pone.0285242

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