TDP-43 pathology in Drosophila induces glial-cell type specific toxicity that can be ameliorated by knock-down of SF2/SRSF1

Accumulation of cytoplasmic inclusions of TAR-DNA binding protein 43 (TDP-43) is seen in both neurons and glia in a range of neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and Alzheimer’s disease (AD). Disease progression involves non-cell a...

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Detalles Bibliográficos
Autores principales: Krupp, Sarah, Hubbard, Isabel, Tam, Oliver, Hammell, Gale M., Dubnau, Josh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10553832/
https://www.ncbi.nlm.nih.gov/pubmed/37747929
http://dx.doi.org/10.1371/journal.pgen.1010973

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10553832/
https://www.ncbi.nlm.nih.gov/pubmed/37747929
http://dx.doi.org/10.1371/journal.pgen.1010973

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