The transcription factor DUX4 orchestrates translational reprogramming by broadly suppressing translation efficiency and promoting expression of DUX4-induced mRNAs

Translational control is critical for cell fate transitions during development, lineage specification, and tumorigenesis. Here, we show that the transcription factor double homeobox protein 4 (DUX4), and its previously characterized transcriptional program, broadly regulates translation to change th...

Descripción completa

Detalles Bibliográficos
Autores principales: Hamm, Danielle C., Paatela, Ellen M., Bennett, Sean R., Wong, Chao-Jen, Campbell, Amy E., Wladyka, Cynthia L., Smith, Andrew A., Jagannathan, Sujatha, Hsieh, Andrew C., Tapscott, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Short Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10553841/
https://www.ncbi.nlm.nih.gov/pubmed/37747887
http://dx.doi.org/10.1371/journal.pbio.3002317

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10553841/
https://www.ncbi.nlm.nih.gov/pubmed/37747887
http://dx.doi.org/10.1371/journal.pbio.3002317

Ejemplares similares