A Proofreading Mutation with an Allosteric Effect Allows a Cluster of SARS-CoV-2 Viruses to Rapidly Evolve

The RNA-dependent RNA polymerase of the severe acute respiratory syndrome coronavirus 2 virus is error prone, with errors being corrected by the exonuclease (NSP14) proofreading mechanism. However, the mutagenesis and subsequent evolutionary trajectory of the virus is mediated by the delicate interp...

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Detalles Bibliográficos
Autores principales: Mack, Andrew H, Menzies, Georgina, Southgate, Alex, Jones, D Dafydd, Connor, Thomas R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Discoveries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10553922/
https://www.ncbi.nlm.nih.gov/pubmed/37738143
http://dx.doi.org/10.1093/molbev/msad209

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10553922/
https://www.ncbi.nlm.nih.gov/pubmed/37738143
http://dx.doi.org/10.1093/molbev/msad209

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