Cargando…

CycloZ Improves Hyperglycemia and Lipid Metabolism by Modulating Lysine Acetylation in KK-Ay Mice

BACKGROUND: CycloZ, a combination of cyclo-His-Pro and zinc, has anti-diabetic activity. However, its exact mode of action remains to be elucidated. METHODS: KK-Ay mice, a type 2 diabetes mellitus (T2DM) model, were administered CycloZ either as a preventive intervention, or as a therapy. Glycemic c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jeon, Jongsu, Lee, Dohyun, Kim, Bobae, Park, Bo-Yoon, Oh, Chang Joo, Kim, Min-Ji, Jeon, Jae-Han, Lee, In-Kyu, Park, Onyu, Baek, Seoyeong, Lim, Chae Won, Ryu, Dongryeol, Fang, Sungsoon, Auwerx, Johan, Kim, Kyong-Tai, Jung, Hoe-Yune
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Diabetes Association 2023
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10555534/ https://www.ncbi.nlm.nih.gov/pubmed/37098411 http://dx.doi.org/10.4093/dmj.2022.0244

Ejemplares similares

Cyclo(His-Pro): A further step in the management of steatohepatitis
por: De Masi, Alessia, et al.
Publicado: (2023)

Royal jelly improves hyperglycemia in obese/diabetic KK-Ay mice
por: YOSHIDA, Mei, et al.
Publicado: (2016)

Nordic Seaweed and Diabetes Prevention: Exploratory Studies in KK-Ay Mice
por: Sørensen, Lasse E., et al.
Publicado: (2019)

Studies of pathology and pharmacology of diabetic encephalopathy with KK‐Ay mouse model
por: Shi, Si, et al.
Publicado: (2019)

Qiwei granules alleviates podocyte lesion in kidney of diabetic KK-Ay mice
por: Zhou, Jingxin, et al.
Publicado: (2015)

Effect of Bushen Huoxue Prescription on Cognitive Dysfunction of KK-Ay Type 2 Diabetic Mice
por: Zhao, Shao-Yang, et al.
Publicado: (2021)

Skin, Liver, and Kidney Interactions Contribute to Skin Dryness in Aging KK-Ay/Tajcl Mice
por: Hiramoto, Keiichi, et al.
Publicado: (2022)

10-Hydroxy-2-decenoic acid, a natural product, improves hyperglycemia and insulin resistance in obese/diabetic KK-Ay mice, but does not prevent obesity
por: WATADANI, Risa, et al.
Publicado: (2017)

Bone marrow transplantation as a strategy for treatment of non-insulin- dependent diabetes mellitus in KK-Ay mice
Publicado: (1992)

Hypoglycemic Activity and the Potential Mechanism of the Flavonoid Rich Extract from Sophora tonkinensis Gagnep. in KK-Ay Mice
por: Huang, Mi, et al.
Publicado: (2016)

Suramin prevents the development of diabetic kidney disease by inhibiting NLRP3 inflammasome activation in KK‐Ay mice
por: Oda, Kaori, et al.
Publicado: (2022)

Dementia Is Induced via the AGEs/Iba1/iNOS Pathway in Aged KK-Ay/Tajcl Mice
por: Hiramoto, Keiichi, et al.
Publicado: (2023)

Lessons From the KK-Ay Mouse, a Spontaneous Animal Model for the Treatment of Human Type 2 Diabetic Nephropathy
por: Tomino, Yasuhiko
Publicado: (2012)

Empagliflozin Induces White Adipocyte Browning and Modulates Mitochondrial Dynamics in KK Cg-Ay/J Mice and Mouse Adipocytes
por: Xu, Linxin, et al.
Publicado: (2021)

Changes in the AGE/Macrophage/TNF-α Pathway Affect Skin Dryness during KK-Ay/Tajcl Mice Aging
por: Hiramoto, Keiichi, et al.
Publicado: (2023)

High Insulin Levels in KK-Ay Diabetic Mice Cause Increased Cortical Bone Mass and Impaired Trabecular Micro-Structure
por: Fu, Cen, et al.
Publicado: (2015)

Acetate alters expression of genes involved in beige adipogenesis in 3T3-L1 cells and obese KK-Ay mice
por: Hanatani, Satoko, et al.
Publicado: (2016)

Oral Administration of Lipopolysaccharide Enhances Insulin Signaling-Related Factors in the KK/Ay Mouse Model of Type 2 Diabetes Mellitus
por: Yamamoto, Kazushi, et al.
Publicado: (2023)

Anti-diabetic effects and mechanisms of action of a Chinese herbal medicine preparation JQ-R in vitro and in diabetic KK(Ay) mice
por: Liu, Quan, et al.
Publicado: (2017)

Xanthine Oxidase Inhibitor Febuxostat Exerts an Anti-Inflammatory Action and Protects against Diabetic Nephropathy Development in KK-Ay Obese Diabetic Mice
por: Mizuno, Yu, et al.
Publicado: (2019)

Correction to: Chronic administration of palmitoleic acid reduces insulin resistance and hepatic lipid accumulation in KK-Ay Mice with genetic type 2 diabetes
por: Yang, Zhi-Hong, et al.
Publicado: (2021)

Jiangtang decoction ameliorate diabetic nephropathy through the regulation of PI3K/Akt-mediated NF-κB pathways in KK-Ay mice
por: Hong, Jin-Ni, et al.
Publicado: (2017)

PHPB Attenuated Cognitive Impairment in Type 2 Diabetic KK-Ay Mice by Modulating SIRT1/Insulin Signaling Pathway and Inhibiting Generation of AGEs
por: Li, Jiang, et al.
Publicado: (2023)

Ay mi!
por: Guillaume, de Machaut, ca. 1300-1377
Publicado: (1997)

Antidiabetic Activity of a Flavonoid-Rich Extract From Sophora davidii (Franch.) Skeels in KK-Ay Mice via Activation of AMP-Activated Protein Kinase
por: Huang, Yun, et al.
Publicado: (2018)

¡Ay cosita! : sones campesinos.
Publicado: (2001)

¡Ay, Nicaragua, Nicaraguita!
Publicado: (1993)

Ay, Nicaragua, Nicaragüita! /
por: Roffiel, Rosa María
Publicado: (1986)

Study of a ($KK\pi$) enhancement in $KK3\pi$ annihilations
por: Armenteros, R, et al.
Publicado: (1966)

Implementation of KK for DELPHI (DElKK version 4.14/6)
por: Andringa, S, et al.
Publicado: (2003)

Ay, Europa! : pequeños escritos políticos XI /
por: Habermas, Jürgen
Publicado: (2009)

Molecular Epidemiology of AY.28 and AY.104 Delta Sub-lineages in Sri Lanka
por: Ranasinghe, Diyanath, et al.
Publicado: (2022)

UPLC-Q/TOF-MS-Based Serum Metabolomics Reveals Hypoglycemic Effects of Rehmannia glutinosa, Coptis chinensis and Their Combination on High-Fat-Diet-Induced Diabetes in KK-Ay Mice
por: Qin, Zhenxian, et al.
Publicado: (2018)

Elements of KK-theory
por: Jensen, Kjeld Knudsen, et al.
Publicado: (1991)

KK states and the radion
por: Randall, Lisa
Publicado: (2011)

Coupled-channel analysis of the pi eta and KK systems near KK threshold
por: Flatte, S M
Publicado: (1976)

Parçacık deneyi gelecek ay
Publicado: (2008)

Parçacık deneyi gelecek ay
Publicado: (2008)

Myricetin improves endurance capacity and mitochondrial density by activating SIRT1 and PGC-1α
por: Jung, Hoe-Yune, et al.
Publicado: (2017)

Ay amor! Spanish 17th c. songs & theatre music.
Publicado: (1990)

Cannot write session to /tmp/vufind_sessions/sess_47ugbocshgaejl2nevia3abk26