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Spatiotemporal, optogenetic control of gene expression in organoids

Organoids derived from stem cells have become an increasingly important tool for studying human development and modeling disease. However, methods are still needed to control and study spatiotemporal patterns of gene expression in organoids. Here we combined optogenetics and gene perturbation techno...

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Detalles Bibliográficos
Autores principales: Legnini, Ivano, Emmenegger, Lisa, Zappulo, Alessandra, Rybak-Wolf, Agnieszka, Wurmus, Ricardo, Martinez, Anna Oliveras, Jara, Cledi Cerda, Boltengagen, Anastasiya, Hessler, Talé, Mastrobuoni, Guido, Kempa, Stefan, Zinzen, Robert, Woehler, Andrew, Rajewsky, Nikolaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10555836/
https://www.ncbi.nlm.nih.gov/pubmed/37735569
http://dx.doi.org/10.1038/s41592-023-01986-w