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Metabolic profiling to evaluate the impact of amantadine and rimantadine on the secondary metabolism of a model organism

Metabolic profiling offers huge potential to highlight markers and mechanisms in support of toxicology and pathology investigations during drug development. The main objective was to modify therapy with adamantane derivatives: amantadine and rimantadine, to increase their bioavailability and evaluat...

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Autores principales: Kostina-Bednarz, Marianna, Płonka, Joanna, Barchanska, Hanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10555991/
https://www.ncbi.nlm.nih.gov/pubmed/37798340
http://dx.doi.org/10.1038/s41598-023-43540-w
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author Kostina-Bednarz, Marianna
Płonka, Joanna
Barchanska, Hanna
author_facet Kostina-Bednarz, Marianna
Płonka, Joanna
Barchanska, Hanna
author_sort Kostina-Bednarz, Marianna
collection PubMed
description Metabolic profiling offers huge potential to highlight markers and mechanisms in support of toxicology and pathology investigations during drug development. The main objective was to modify therapy with adamantane derivatives: amantadine and rimantadine, to increase their bioavailability and evaluate the influence of such therapy on drug metabolism using Saccharomyces cerevisiae as the model organism. In this study, the profile of endogenous metabolites of a model organism was measured and interpreted to provide an opportunity to investigate changes induced by treatment with amantadine and rimantadine. It was found that resveratrol supplementation synergistically enhanced the effects of amantadine treatment and increased rimantadine metabolism, potentially reducing side effects. The fingerprinting strategy was used as an efficient technique for qualitatively evaluating and monitoring changes in the profiles of endogenous components and their contents in a model organism. Chemometric tools were employed to find marker compounds that can be defined as characteristic indicators of a pharmacological response to a therapeutic intervention. An improved understanding of the mechanisms involved in drug effect and an increased ability to predict individual variations in the drug response of organisms will improve the treatment process and the development of new therapies.
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spelling pubmed-105559912023-10-07 Metabolic profiling to evaluate the impact of amantadine and rimantadine on the secondary metabolism of a model organism Kostina-Bednarz, Marianna Płonka, Joanna Barchanska, Hanna Sci Rep Article Metabolic profiling offers huge potential to highlight markers and mechanisms in support of toxicology and pathology investigations during drug development. The main objective was to modify therapy with adamantane derivatives: amantadine and rimantadine, to increase their bioavailability and evaluate the influence of such therapy on drug metabolism using Saccharomyces cerevisiae as the model organism. In this study, the profile of endogenous metabolites of a model organism was measured and interpreted to provide an opportunity to investigate changes induced by treatment with amantadine and rimantadine. It was found that resveratrol supplementation synergistically enhanced the effects of amantadine treatment and increased rimantadine metabolism, potentially reducing side effects. The fingerprinting strategy was used as an efficient technique for qualitatively evaluating and monitoring changes in the profiles of endogenous components and their contents in a model organism. Chemometric tools were employed to find marker compounds that can be defined as characteristic indicators of a pharmacological response to a therapeutic intervention. An improved understanding of the mechanisms involved in drug effect and an increased ability to predict individual variations in the drug response of organisms will improve the treatment process and the development of new therapies. Nature Publishing Group UK 2023-10-05 /pmc/articles/PMC10555991/ /pubmed/37798340 http://dx.doi.org/10.1038/s41598-023-43540-w Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Kostina-Bednarz, Marianna
Płonka, Joanna
Barchanska, Hanna
Metabolic profiling to evaluate the impact of amantadine and rimantadine on the secondary metabolism of a model organism
title Metabolic profiling to evaluate the impact of amantadine and rimantadine on the secondary metabolism of a model organism
title_full Metabolic profiling to evaluate the impact of amantadine and rimantadine on the secondary metabolism of a model organism
title_fullStr Metabolic profiling to evaluate the impact of amantadine and rimantadine on the secondary metabolism of a model organism
title_full_unstemmed Metabolic profiling to evaluate the impact of amantadine and rimantadine on the secondary metabolism of a model organism
title_short Metabolic profiling to evaluate the impact of amantadine and rimantadine on the secondary metabolism of a model organism
title_sort metabolic profiling to evaluate the impact of amantadine and rimantadine on the secondary metabolism of a model organism
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10555991/
https://www.ncbi.nlm.nih.gov/pubmed/37798340
http://dx.doi.org/10.1038/s41598-023-43540-w
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