Temporal serum metabolomic and lipidomic analyses distinguish patients with access-related hand disability following arteriovenous fistula creation

For end-stage kidney disease (ESKD) patients, hemodialysis requires durable vascular access which is often surgically created using an arteriovenous fistula (AVF). However, some ESKD patients that undergo AVF placement develop access-related hand dysfunction (ARHD) through unknown mechanisms. In thi...

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Autores principales: Khattri, Ram B., Louis, Lauryn Z., Kim, Kyoungrae, Anderson, Erik M., Fazzone, Brian, Harland, Kenneth C., Hu, Qiongyao, O’Malley, Kerri A., Berceli, Scott A., Wymer, James, Ryan, Terence E., Scali, Salvatore T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10555997/
https://www.ncbi.nlm.nih.gov/pubmed/37798334
http://dx.doi.org/10.1038/s41598-023-43664-z
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author Khattri, Ram B.
Louis, Lauryn Z.
Kim, Kyoungrae
Anderson, Erik M.
Fazzone, Brian
Harland, Kenneth C.
Hu, Qiongyao
O’Malley, Kerri A.
Berceli, Scott A.
Wymer, James
Ryan, Terence E.
Scali, Salvatore T.
author_facet Khattri, Ram B.
Louis, Lauryn Z.
Kim, Kyoungrae
Anderson, Erik M.
Fazzone, Brian
Harland, Kenneth C.
Hu, Qiongyao
O’Malley, Kerri A.
Berceli, Scott A.
Wymer, James
Ryan, Terence E.
Scali, Salvatore T.
author_sort Khattri, Ram B.
collection PubMed
description For end-stage kidney disease (ESKD) patients, hemodialysis requires durable vascular access which is often surgically created using an arteriovenous fistula (AVF). However, some ESKD patients that undergo AVF placement develop access-related hand dysfunction (ARHD) through unknown mechanisms. In this study, we sought to determine if changes in the serum metabolome could distinguish ESKD patients that develop ARHD from those that have normal hand function following AVF creation. Forty-five ESKD patients that underwent first-time AVF creation were included in this study. Blood samples were obtained pre-operatively and 6-weeks post-operatively and metabolites were extracted and analyzed using nuclear magnetic resonance spectroscopy. Patients underwent thorough examination of hand function at both timepoints using the following assessments: grip strength manometry, dexterity, sensation, motor and sensory nerve conduction testing, hemodynamics, and the Disabilities of the Arm, Shoulder, and Hand (DASH) questionnaire. Nineteen of the forty-five patients displayed overt weakness using grip strength manometry (P < 0.0001). Unfortunately, the serum metabolome was indistinguishable between patients with and without weakness following AVF surgery. However, a significant correlation was found between the change in tryptophan levels and the change in grip strength suggesting a possible role of tryptophan-derived uremic metabolites in post-AVF hand-associated weakness. Compared to grip strength, changes in dexterity and sensation were smaller than those observed in grip strength, however, post-operative decreases in phenylalanine, glycine, and alanine were unique to patients that developed signs of motor or sensory disability following AVF creation.
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spelling pubmed-105559972023-10-07 Temporal serum metabolomic and lipidomic analyses distinguish patients with access-related hand disability following arteriovenous fistula creation Khattri, Ram B. Louis, Lauryn Z. Kim, Kyoungrae Anderson, Erik M. Fazzone, Brian Harland, Kenneth C. Hu, Qiongyao O’Malley, Kerri A. Berceli, Scott A. Wymer, James Ryan, Terence E. Scali, Salvatore T. Sci Rep Article For end-stage kidney disease (ESKD) patients, hemodialysis requires durable vascular access which is often surgically created using an arteriovenous fistula (AVF). However, some ESKD patients that undergo AVF placement develop access-related hand dysfunction (ARHD) through unknown mechanisms. In this study, we sought to determine if changes in the serum metabolome could distinguish ESKD patients that develop ARHD from those that have normal hand function following AVF creation. Forty-five ESKD patients that underwent first-time AVF creation were included in this study. Blood samples were obtained pre-operatively and 6-weeks post-operatively and metabolites were extracted and analyzed using nuclear magnetic resonance spectroscopy. Patients underwent thorough examination of hand function at both timepoints using the following assessments: grip strength manometry, dexterity, sensation, motor and sensory nerve conduction testing, hemodynamics, and the Disabilities of the Arm, Shoulder, and Hand (DASH) questionnaire. Nineteen of the forty-five patients displayed overt weakness using grip strength manometry (P < 0.0001). Unfortunately, the serum metabolome was indistinguishable between patients with and without weakness following AVF surgery. However, a significant correlation was found between the change in tryptophan levels and the change in grip strength suggesting a possible role of tryptophan-derived uremic metabolites in post-AVF hand-associated weakness. Compared to grip strength, changes in dexterity and sensation were smaller than those observed in grip strength, however, post-operative decreases in phenylalanine, glycine, and alanine were unique to patients that developed signs of motor or sensory disability following AVF creation. Nature Publishing Group UK 2023-10-05 /pmc/articles/PMC10555997/ /pubmed/37798334 http://dx.doi.org/10.1038/s41598-023-43664-z Text en © This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Khattri, Ram B.
Louis, Lauryn Z.
Kim, Kyoungrae
Anderson, Erik M.
Fazzone, Brian
Harland, Kenneth C.
Hu, Qiongyao
O’Malley, Kerri A.
Berceli, Scott A.
Wymer, James
Ryan, Terence E.
Scali, Salvatore T.
Temporal serum metabolomic and lipidomic analyses distinguish patients with access-related hand disability following arteriovenous fistula creation
title Temporal serum metabolomic and lipidomic analyses distinguish patients with access-related hand disability following arteriovenous fistula creation
title_full Temporal serum metabolomic and lipidomic analyses distinguish patients with access-related hand disability following arteriovenous fistula creation
title_fullStr Temporal serum metabolomic and lipidomic analyses distinguish patients with access-related hand disability following arteriovenous fistula creation
title_full_unstemmed Temporal serum metabolomic and lipidomic analyses distinguish patients with access-related hand disability following arteriovenous fistula creation
title_short Temporal serum metabolomic and lipidomic analyses distinguish patients with access-related hand disability following arteriovenous fistula creation
title_sort temporal serum metabolomic and lipidomic analyses distinguish patients with access-related hand disability following arteriovenous fistula creation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10555997/
https://www.ncbi.nlm.nih.gov/pubmed/37798334
http://dx.doi.org/10.1038/s41598-023-43664-z
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