Autoantibody binding and unique enzyme-substrate intermediate conformation of human transglutaminase 3

Transglutaminase 3 (TG3), the autoantigen of dermatitis herpetiformis (DH), is a calcium dependent enzyme that targets glutamine residues in polypeptides for either transamidation or deamidation modifications. To become catalytically active TG3 requires proteolytic cleavage between the core domain a...

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Detalles Bibliográficos
Autores principales: Heggelund, Julie Elisabeth, Das, Saykat, Stamnaes, Jorunn, Iversen, Rasmus, Sollid, Ludvig M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10556103/
https://www.ncbi.nlm.nih.gov/pubmed/37798283
http://dx.doi.org/10.1038/s41467-023-42004-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10556103/
https://www.ncbi.nlm.nih.gov/pubmed/37798283
http://dx.doi.org/10.1038/s41467-023-42004-z

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