Cargando…

Autoantibody binding and unique enzyme-substrate intermediate conformation of human transglutaminase 3

Transglutaminase 3 (TG3), the autoantigen of dermatitis herpetiformis (DH), is a calcium dependent enzyme that targets glutamine residues in polypeptides for either transamidation or deamidation modifications. To become catalytically active TG3 requires proteolytic cleavage between the core domain a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Heggelund, Julie Elisabeth, Das, Saykat, Stamnaes, Jorunn, Iversen, Rasmus, Sollid, Ludvig M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10556103/ https://www.ncbi.nlm.nih.gov/pubmed/37798283 http://dx.doi.org/10.1038/s41467-023-42004-z

Ejemplares similares

Transglutaminase 2 affinity and enzyme‐substrate intermediate stability as determining factors for T‐cell responses to gluten peptides in celiac disease
por: Amundsen, Sunniva F., et al.
Publicado: (2022)

Separate Gut Plasma Cell Populations Produce Auto‐Antibodies against Transglutaminase 2 and Transglutaminase 3 in Dermatitis Herpetiformis
por: Das, Saykat, et al.
Publicado: (2023)

Enhanced B-Cell Receptor Recognition of the Autoantigen Transglutaminase 2 by Efficient Catalytic Self-Multimerization
por: Stamnaes, Jorunn, et al.
Publicado: (2015)

Activation and Inhibition of Transglutaminase 2 in Mice
por: Dafik, Laila, et al.
Publicado: (2012)

Abundance and unique repertoire of plasma cells secreting IgA autoantibodies to transglutaminase 2 in the intestinal lesion of celiac disease
por: Di Niro, Roberto, et al.
Publicado: (2012)

Expression of transglutaminase 2 in human gut epithelial cells: Implications for coeliac disease
por: Amundsen, Sunniva F., et al.
Publicado: (2023)

Injection of prototypic celiac anti-transglutaminase 2 antibodies in mice does not cause enteropathy
por: Lindstad, Christian B., et al.
Publicado: (2022)

Structural Basis for Antigen Recognition by Transglutaminase 2-specific Autoantibodies in Celiac Disease
por: Chen, Xi, et al.
Publicado: (2015)

TG2-gluten complexes as antigens for gluten-specific and transglutaminase-2 specific B cells in celiac disease
por: Lindstad, Christian B., et al.
Publicado: (2021)

B cell tolerance and antibody production to the celiac disease autoantigen transglutaminase 2
por: du Pré, M. Fleur, et al.
Publicado: (2019)

In Well‐Treated Celiac Patients Low‐Level Mucosal Inflammation Predicts Response to 14‐day Gluten Challenge
por: Stamnaes, Jorunn, et al.
Publicado: (2021)

The Preferred Substrates for Transglutaminase 2 in a Complex Wheat Gluten Digest Are Peptide Fragments Harboring Celiac Disease T-Cell Epitopes
por: Dørum, Siri, et al.
Publicado: (2010)

Anti-PAD4 autoantibodies in rheumatoid arthritis: levels in serum over time and impact on PAD4 activity as measured with a small synthetic substrate
por: Pollmann, Sylvie, et al.
Publicado: (2011)

Unique Biradical Intermediate in the Mechanism of the Heme Enzyme Chlorite Dismutase
por: Püschmann, Julia, et al.
Publicado: (2021)

Elevated Transglutaminase Activity Triggers Angiotensin Receptor Activating Autoantibody Production and Pathophysiology of Preeclampsia
por: Liu, Chen, et al.
Publicado: (2015)

Intestinal Anti-tissue Transglutaminase2 Autoantibodies: Pathogenic and Clinical Implications for Celiac Disease
por: Maglio, Mariantonia, et al.
Publicado: (2020)

Bcr is a substrate for Transglutaminase 2 cross-linking activity
por: Yi, Sun-Ju, et al.
Publicado: (2011)

Transglutaminase 2 Undergoes a Large Conformational Change upon Activation
por: Pinkas, Daniel M, et al.
Publicado: (2007)

Intracellular Localization and Conformational State of Transglutaminase 2: Implications for Cell Death
por: Gundemir, Soner, et al.
Publicado: (2009)

Sulfated glycosaminoglycans inhibit transglutaminase 2 by stabilizing its closed conformation
por: Müller, Claudia Damaris, et al.
Publicado: (2022)

The Impact of N(ε)-Acryloyllysine Piperazides on the Conformational Dynamics of Transglutaminase 2
por: Heerwig, Andreas, et al.
Publicado: (2023)

Computational remodeling of an enzyme conformational landscape for altered substrate selectivity
por: St-Jacques, Antony D., et al.
Publicado: (2023)

The Intestinal T Cell Response to α-Gliadin in Adult Celiac Disease Is Focused on a Single Deamidated Glutamine Targeted by Tissue Transglutaminase
por: Arentz-Hansen, Helene, et al.
Publicado: (2000)

Maternal celiac disease autoantibodies bind directly to syncytiotrophoblast and inhibit placental tissue transglutaminase activity
por: Anjum, Naheed, et al.
Publicado: (2009)

Higher Sensitivity and Earlier Identification of Celiac Disease Autoimmunity by a Nonradioactive Assay for Transglutaminase Autoantibodies
por: Zhao, Zhiyuan, et al.
Publicado: (2016)

Isozyme-specific comprehensive characterization of transglutaminase-crosslinked substrates in kidney fibrosis
por: Tatsukawa, Hideki, et al.
Publicado: (2018)

Allosteric Activation of Transglutaminase 2 via Inducing an “Open” Conformation for Osteoblast Differentiation
por: Yang, Zhuo, et al.
Publicado: (2023)

Membrane Allostery and Unique Hydrophobic Sites Promote Enzyme Substrate Specificity
por: Mouchlis, Varnavas D., et al.
Publicado: (2018)

Low prevalence of IgA anti-transglutaminase 1, 2, and 3 autoantibodies in children with atopic dermatitis
por: Ress, Krista, et al.
Publicado: (2014)

Celiac Disease-Type Tissue Transglutaminase Autoantibody Deposits in Kidney Biopsies of Patients with IgA Nephropathy
por: Nurmi, Rakel, et al.
Publicado: (2021)

Coeliac disease: the showcase of interaction between genes, environment and immunology in chronic tissue inflammation
por: Sollid, Ludvig M
Publicado: (2011)

Substrate specificity of microbial transglutaminase as revealed by three-dimensional docking simulation and mutagenesis
por: Tagami, Uno, et al.
Publicado: (2009)

Design of highly active substrates using molecular docking for microbial transglutaminase detection
por: Zou, Longhao, et al.
Publicado: (2023)

Using FLIM-FRET to Measure Conformational Changes of Transglutaminase Type 2 in Live Cells
por: Caron, Nicholas S., et al.
Publicado: (2012)

Conformational changes and translocation of tissue-transglutaminase to the plasma membranes: role in cancer cell migration
por: Kumar, Ambrish, et al.
Publicado: (2014)

Author Correction: Sulfated glycosaminoglycans inhibit transglutaminase 2 by stabilizing its closed conformation
por: Müller, Claudia Damaris, et al.
Publicado: (2022)

A partially-open inward-facing intermediate conformation of LeuT is associated with Na(+) release and substrate transport
por: Terry, Daniel S., et al.
Publicado: (2018)

Hybrid selection based multi/many-objective evolutionary algorithm
por: Dutta, Saykat, et al.
Publicado: (2022)

Thioredoxin A Active-Site Mutants Form Mixed Disulfide Dimers That Resemble Enzyme–Substrate Reaction Intermediates
por: Kouwen, Thijs R.H.M., et al.
Publicado: (2008)

Characterization of Gelatin Hydrogels Cross-Linked with Microbial Transglutaminase as Engineered Skeletal Muscle Substrates
por: Gupta, Divya, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_22eejm2j0q6j983de5cn2dd1m3