Cargando…

Autoantibody binding and unique enzyme-substrate intermediate conformation of human transglutaminase 3

Transglutaminase 3 (TG3), the autoantigen of dermatitis herpetiformis (DH), is a calcium dependent enzyme that targets glutamine residues in polypeptides for either transamidation or deamidation modifications. To become catalytically active TG3 requires proteolytic cleavage between the core domain a...

Descripción completa

Detalles Bibliográficos
Autores principales: Heggelund, Julie Elisabeth, Das, Saykat, Stamnaes, Jorunn, Iversen, Rasmus, Sollid, Ludvig M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10556103/
https://www.ncbi.nlm.nih.gov/pubmed/37798283
http://dx.doi.org/10.1038/s41467-023-42004-z

Ejemplares similares