The USP46 deubiquitylase complex increases Wingless/Wnt signaling strength by stabilizing Arrow/LRP6

The control of Wnt receptor abundance is critical for animal development and to prevent tumorigenesis, but the mechanisms that mediate receptor stabilization remain uncertain. We demonstrate that stabilization of the essential Wingless/Wnt receptor Arrow/LRP6 by the evolutionarily conserved Usp46-Ua...

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Detalles Bibliográficos
Autores principales: Spencer, Zachary T., Ng, Victoria H., Benchabane, Hassina, Siddiqui, Ghalia Saad, Duwadi, Deepesh, Maines, Ben, Bryant, Jamal M., Schwarzkopf, Anna, Yuan, Kai, Kassel, Sara N., Mishra, Anant, Pimentel, Ashley, Lebensohn, Andres M., Rohatgi, Rajat, Gerber, Scott A., Robbins, David J., Lee, Ethan, Ahmed, Yashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10556106/
https://www.ncbi.nlm.nih.gov/pubmed/37798281
http://dx.doi.org/10.1038/s41467-023-41843-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10556106/
https://www.ncbi.nlm.nih.gov/pubmed/37798281
http://dx.doi.org/10.1038/s41467-023-41843-0

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