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The USP46 deubiquitylase complex increases Wingless/Wnt signaling strength by stabilizing Arrow/LRP6
The control of Wnt receptor abundance is critical for animal development and to prevent tumorigenesis, but the mechanisms that mediate receptor stabilization remain uncertain. We demonstrate that stabilization of the essential Wingless/Wnt receptor Arrow/LRP6 by the evolutionarily conserved Usp46-Ua...
Autores principales: | Spencer, Zachary T., Ng, Victoria H., Benchabane, Hassina, Siddiqui, Ghalia Saad, Duwadi, Deepesh, Maines, Ben, Bryant, Jamal M., Schwarzkopf, Anna, Yuan, Kai, Kassel, Sara N., Mishra, Anant, Pimentel, Ashley, Lebensohn, Andres M., Rohatgi, Rajat, Gerber, Scott A., Robbins, David J., Lee, Ethan, Ahmed, Yashi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10556106/ https://www.ncbi.nlm.nih.gov/pubmed/37798281 http://dx.doi.org/10.1038/s41467-023-41843-0 |
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