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Impact of BRAF(V600E) mutation on aggressiveness and outcomes in adult clonal histiocytosis
Histiocytoses encompass a wide spectrum of diseases, all characterized by tissue infiltration by CD68+ histiocytes. Most adult histiocytoses are considered clonal diseases because they highlight recurrent somatic mutations in the MAP-kinase pathway gene, primarily BRAF. The presence of BRAF mutation...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10556468/ https://www.ncbi.nlm.nih.gov/pubmed/37809108 http://dx.doi.org/10.3389/fimmu.2023.1260193 |