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Impact of BRAF(V600E) mutation on aggressiveness and outcomes in adult clonal histiocytosis

Histiocytoses encompass a wide spectrum of diseases, all characterized by tissue infiltration by CD68+ histiocytes. Most adult histiocytoses are considered clonal diseases because they highlight recurrent somatic mutations in the MAP-kinase pathway gene, primarily BRAF. The presence of BRAF mutation...

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Detalles Bibliográficos
Autores principales: Razanamahery, Jerome, Godot, Amelie, Leguy-Seguin, Vanessa, Samson, M., Audia, Sylvain, Bonnotte, Bernard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10556468/
https://www.ncbi.nlm.nih.gov/pubmed/37809108
http://dx.doi.org/10.3389/fimmu.2023.1260193