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DAT (deacylating autotransporter toxin) from Bordetella parapertussis demyristoylates Gα(i) GTPases and contributes to cough

The pathogenic bacteria Bordetella pertussis and Bordetella parapertussis cause pertussis (whooping cough) and pertussis-like disease, respectively, both of which are characterized by paroxysmal coughing. We previously reported that pertussis toxin (PTx), which inactivates heterotrimeric GTPases of...

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Detalles Bibliográficos
Autores principales: Hiramatsu, Yukihiro, Nishida, Takashi, Ota, Natsuko, Tamaki, Yuki, Nugraha, Dendi K., Horiguchi, Yasuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10556565/
https://www.ncbi.nlm.nih.gov/pubmed/37748060
http://dx.doi.org/10.1073/pnas.2308260120