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Methylmercury (MeHg) transcriptionally regulates NAD(P)H:quinone oxidoreductase 1 (NQO1) in Hepa-1c1c7 cells

The detoxification of quinones through NAD(P)H:quinone oxidoreductase (NQO1) is a crucial mechanism to maintain cellular homeostasis. The exposure to heavy metals, specifically methylmercury (MeHg), induces several antioxidant enzymes, including NQO1. The nuclear factor erythroid 2-related factor-2...

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Detalles Bibliográficos
Autores principales: Alqahtani, Mohammed A., El-Ghiaty, Mahmoud A., El-Mahrouk, Sara R., El-Kadi, Ayman O.S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10556580/
https://www.ncbi.nlm.nih.gov/pubmed/37808441
http://dx.doi.org/10.1016/j.crtox.2023.100126